LMPD Database

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LMP007192

UniProt Annotations

Entry Information
Gene Namesterol 24-C-methyltransferase
Protein EntryERG6_YEAST
UniProt IDP25087
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + 5-alpha-cholesta- 8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5- alpha-cholest-8-en-3-beta-ol.
FunctionCatalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
InteractionQ12066:YDL089W; NbExp=1; IntAct=EBI-6567, EBI-35877; Q12274:YOR097C; NbExp=1; IntAct=EBI-6567, EBI-33978;
MiscellaneousPresent with 53800 molecules/cell in log phase SD medium
MiscellaneousPresent with 53800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwaySteroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.
SubunitInteracts with ERG28. {ECO:0000269|PubMed:15522820, ECO:0000269|PubMed:15995173}.