LMPD Database

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LMP007132

UniProt Annotations

Entry Information
Gene Namechitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Protein EntryALG1_YEAST
UniProt IDP16661
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityGDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.
FunctionParticipates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
InteractionP53954:ALG11; NbExp=2; IntAct=EBI-2206309, EBI-2497; P43636:ALG2; NbExp=2; IntAct=EBI-2206309, EBI-2459;
MiscellaneousPresent with 1890 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
SubunitHomodimer. Interacts with ALG2 and ALG11. {ECO:0000269|PubMed:15044395}.