LMPD Database

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LMP007040

UniProt Annotations

Entry Information
Gene Namebifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Protein EntryFNTA_YEAST
UniProt IDP29703
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
FunctionCatalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
InteractionP18898:CDC43; NbExp=3; IntAct=EBI-14814, EBI-3961; P22007:RAM1; NbExp=4; IntAct=EBI-14814, EBI-14806;
MiscellaneousPresent with 396 molecules/cell in log phase SD medium
MiscellaneousPresent with 396 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the protein prenyltransferase subunit alpha family
SimilarityBelongs to the protein prenyltransferase subunit alpha family. {ECO:0000305}.
SimilarityContains 5 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}.
SubunitHeterodimer of an alpha and a beta subunit.