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LMPD Database

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LMP006986

UniProt Annotations

Entry Information

Gene Name	beta-glucan synthesis-associated protein KRE6
Protein Entry	KRE6_YEAST
UniProt ID	P32486
Species	Yeast (S288c)

Comments

Comment type	Description
Function	Involved in the synthesis of (1->6)- and (1->3)-beta-D- glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-structure that acts as an acceptor site for the addition of (1->6)-beta-D-glucan at the cell surface. {ECO:0000269\|PubMed:10601196, ECO:0000269\|PubMed:12237851, ECO:0000269\|PubMed:15093776}.
Miscellaneous	Present with 4760 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the SKN1/KRE6 family. {ECO:0000305}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269\|PubMed:12237851}; Single-pass type II membrane protein {ECO:0000269\|PubMed:12237851}.
Subunit	The cytoplasmic domain interacts with the actin patch assembly proteins LAS17 and SLA1. Interacts with KEG1. {ECO:0000269\|PubMed:12237851, ECO:0000269\|PubMed:17893149}.