LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006914

UniProt Annotations

Entry Information
Gene NameCld1p
Protein EntryCLD1_YEAST
UniProt IDP53264
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe HXXXXD motif is essential for acyltransferase activity. {ECO:0000250}.
FunctionMitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin. Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin. Has a strong substrate preference for palmitic acid residues and generates monolysocardiolipin for TAZ1- dependent reacylation with unsaturated fatty acids. {ECO:0000269|PubMed:19244244}.
InductionExpressed in aerobic conditions and under genotoxic stress. {ECO:0000269|PubMed:10601195, ECO:0000269|PubMed:15878181}.
InteractionP38822:BZZ1; NbExp=1; IntAct=EBI-23260, EBI-3889;
SimilarityBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:19244244}.