LMPD Database

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LMP006887

UniProt Annotations

Entry Information
Gene NameNum1p
Protein EntryNUM1_YEAST
UniProt IDQ00402
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionControls nuclear migration. NUM1 specifically controls the interaction of the bud neck cytoskeleton with the pre- divisional G2 nucleus. Functions in dynein-anchoring. During late anaphase forms dynein-interacting cortical microtubule capture sites at both cellular poles. This leads to dynein-dependent sliding of the microtubules in the bud. {ECO:0000269|PubMed:11121446, ECO:0000269|PubMed:11266443, ECO:0000269|PubMed:1745235, ECO:0000269|PubMed:7490278}.
InteractionP09734:TUB3; NbExp=2; IntAct=EBI-12386, EBI-18981;
MiscellaneousAdditional regions of lower homology to the repeat consensus (always starting with proline) are found in both flanking domains of the tandem repeats.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationBud tip {ECO:0000269|PubMed:11121446, ECO:0000269|PubMed:11266443, ECO:0000269|PubMed:7490278}.
SubunitInteracts with PAC11 when DYN1 is present, and TUB3
SubunitInteracts with PAC11 when DYN1 is present, and TUB3. {ECO:0000269|PubMed:11266443}.