LMPD Database

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LMP006870

UniProt Annotations

Entry Information
Gene NameNus1p
Protein EntryUPPS_YEAST
UniProt IDQ12063
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000269|PubMed:25066056}.
FunctionWith SRT1 or RER2, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:25066056}.
PathwayProtein modification; protein glycosylation. {ECO:0000305}.
SimilarityBelongs to the UPP synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269|PubMed:10515935, ECO:0000269|PubMed:11086160, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14690591}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
SubunitForms an active dehydrodolichyl diphosphate syntase complex with either SRT1 or RER2. {ECO:0000303|PubMed:25066056}.