LMPD Database

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LMP006855

UniProt Annotations

Entry Information
Gene Name3-dehydrosphinganine reductase
Protein EntryTSC10_YEAST
UniProt IDP38342
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivitySphinganine + NADP(+) = 3-dehydrosphinganine + NADPH.
FunctionCatalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:9804843}.
MiscellaneousPresent with 7700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.