LMPD Database

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LMP006747

UniProt Annotations

Entry Information
Gene NameELOVL fatty acid elongase 1
Protein EntryELOV1_HUMAN
UniProt IDQ9BW60
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BW60-1; Sequence=Displayed; Name=2; IsoId=Q9BW60-2; Sequence=VSP_045436;
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
DomainThe di-lysine motif may confer endoplasmic reticulum localization.
FunctionCondensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO
InteractionO75832:PSMD10; NbExp=1; IntAct=EBI-1050331, EBI-752185; Q6IBS0:TWF2; NbExp=1; IntAct=EBI-1050331, EBI-722204;
Sequence CautionSequence=AAD34083.1; Type=Frameshift; Positions=189; Evidence= ;
SimilarityBelongs to the ELO family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitInteracts with LASS2, TECR and HSD17B12.
Tissue SpecificityUbiquitous.