LMPD Database

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LMP006743

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 1
Protein EntryDGAT1_HUMAN
UniProt IDO75907
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=25.9 uM for retinol ; KM=13.9 uM for palmitoyl coenzyme A ;
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester.
DiseaseDiarrhea 7 (DIAR7) [MIM
Enzyme RegulationXP620 is a selective DGAT1 inhibitor.
FunctionCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO
InteractionQ99IB8:- (xeno); NbExp=2; IntAct=EBI-3906527, EBI-6927873;
PathwayLipid metabolism; glycerolipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Subcellular LocationEndoplasmic reticulum membrane {ECO
SubunitHomodimer or homotetramer.