LMPD Database

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LMP006739

Record overview

LMPD IDLMP006739
Gene ID1646
SpeciesHomo sapiens (Human)
Gene Namealdo-keto reductase family 1, member C2
Gene SymbolAKR1C2
SynonymsAKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD
Alternate namesaldo-keto reductase family 1 member C2; 3-alpha-HSD3; pseudo-chlordecone reductase; type II dihydrodiol dehydrogenase; chlordecone reductase homolog HAKRD; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
Chromosome10
Map Location10p15-p14
EC Number1.-.-.-
SummaryThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for AKR1C2

Proteins

aldo-keto reductase family 1 member C2 isoform 1
Refseq ID:NP_001345
Protein GI:4503285
UniProt ID:P52895
mRNA ID:NM_001354
Length:323
RefSeq Status:REVIEWED
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALE
RSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQR
KLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
 
aldo-keto reductase family 1 member C2 isoform 1
Refseq ID:NP_995317
Protein GI:45446745
UniProt ID:P52895
mRNA ID:NM_205845
Length:323
RefSeq Status:REVIEWED
Protein sequence is identical to GI:4503285 (mRNA isoform)
 
aldo-keto reductase family 1 member C2 isoform 2
Refseq ID:NP_001128713
Protein GI:207028673
UniProt ID:P52895
mRNA ID:NM_001135241
Length:139
RefSeq Status:REVIEWED
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALE
RSLKNLQLDYVDLYLIHFPVSVKEDIGILTWKKSPKHNS