LMPD Database

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LMP006725

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 2
Protein EntryPCAT2_HUMAN
UniProt IDQ7L5N7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L5N7-1; Sequence=Displayed; Name=2; IsoId=Q7L5N7-2; Sequence=VSP_019912; Note=No experimental confirmation available.;
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity.
Enzyme RegulationAcetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged (By similarity).
FunctionPossesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=BAA91199.1; Type=Frameshift; Positions=44; Evidence= ; Sequence=CAE46034.1; Type=Frameshift; Positions=295; Evidence= ;
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SimilarityContains 2 EF-hand domains. {ECO
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane {ECO