LMPD Database

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LMP006701

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Protein EntryPREX1_HUMAN
UniProt IDQ8TCU6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCU6-1; Sequence=Displayed; Name=2; IsoId=Q8TCU6-2; Sequence=VSP_001818, VSP_001819; Name=3; IsoId=Q8TCU6-3; Sequence=VSP_015090, VSP_015091; Note=Gene prediction based on EST data. No experimental confirmation available.;
FunctionFunctions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
InteractionP31750:Akt1 (xeno); NbExp=2; IntAct=EBI-1046542, EBI-298707; P42345:MTOR; NbExp=11; IntAct=EBI-1046542, EBI-359260; Q6R327:RICTOR; NbExp=3; IntAct=EBI-1046542, EBI-1387196; Q8N122:RPTOR; NbExp=2; IntAct=EBI-1046542, EBI-1567928;
SimilarityContains 1 DH (DBL-homology) domain.
SimilarityContains 1 PDZ (DHR) domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 2 DEP domains. {ECO
Subcellular LocationCytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
SubunitInteracts preferentially with RAC2 (By similarity). Interacts with RAC1.
Tissue SpecificityMainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.