LMPD Database

LMP006646

UniProt Annotations

Entry Information

Gene Name	acetyl-CoA carboxylase alpha
Protein Entry	ACACA_HUMAN
UniProt ID	Q7Z5W8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative promoter usage; Named isoforms=4; Name=1; IsoId=Q13085-1; Sequence=Displayed; Name=2; Synonyms=E5A; IsoId=Q13085-2; Sequence=VSP_026099; Name=3; Synonyms=E5B; IsoId=Q13085-3; Sequence=VSP_026098; Name=4; IsoId=Q13085-4; Sequence=VSP_026100;
Catalytic Activity	ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
Catalytic Activity	ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
Cofactor	Name=biotin; Xref=ChEBI
Cofactor	Name=Mn(2+); Xref=ChEBI
Disease	Acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM
Enzyme Regulation	By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.
Function	Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Interaction	O60218:AKR1B10; NbExp=4; IntAct=EBI-717681, EBI-1572139; P38398:BRCA1; NbExp=2; IntAct=EBI-717681, EBI-349905; Q96EB6:SIRT1; NbExp=3; IntAct=EBI-717681, EBI-1802965;
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA
Ptm	Phosphorylation on Ser-1263 is required for interaction with BRCA1. {ECO
Sequence Caution	Sequence=AAP94120.1; Type=Erroneous initiation; Evidence= ;
Similarity	Contains 1 ATP-grasp domain. {ECO
Similarity	Contains 1 biotin carboxylation domain.
Similarity	Contains 1 biotinyl-binding domain.
Similarity	Contains 1 carboxyltransferase domain.
Subcellular Location	Cytoplasm.
Subunit	Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. {ECO
Tissue Specificity	Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Web Resource	Name=Wikipedia; Note=Acetyl-CoA carboxylase entry; URL="http://en.wikipedia.org/wiki/Acetyl-CoA_carboxylase";