LMPD Database

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LMP006629

UniProt Annotations

Entry Information
Gene NameELOVL fatty acid elongase 5
Protein EntryELOV5_HUMAN
UniProt IDQ9NYP7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NYP7-1; Sequence=Displayed; Name=2; IsoId=Q9NYP7-2; Sequence=VSP_045918; Note=No experimental confirmation available.; Name=3; IsoId=Q9NYP7-3; Sequence=VSP_045917, VSP_045919; Note=No experimental confirmation available.;
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
FunctionCondensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. {ECO
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis.
Sequence CautionSequence=AAF16688.1; Type=Erroneous initiation; Evidence= ; Sequence=BAC11178.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the ELO family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityUbiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain.