LMPD Database

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LMP006581

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 3
Protein EntryACSM3_MOUSE
UniProt IDQ3UNX5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UNX5-1; Sequence=Displayed; Name=2; IsoId=Q3UNX5-2; Sequence=VSP_028397; Note=No experimental confirmation available.;
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CautionIt is uncertain whether Met-1 or Met-3 is the initiator. {ECO:0000305}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000269|PubMed:11470804}.
InductionUp-regulated in kidney by androgens. Down-regulated in kidney by estrogens. Levels in kidney are very low in female C57BL/6 mice and in castrated male C57BL/6, 129/SvJ and BALB/c mice. Constitutively expressed in liver. {ECO:0000269|PubMed:15525578, ECO:0000269|PubMed:9449642}.
Sequence CautionSequence=AAC79656.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15248.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL40880.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA37141.1; Type=Frameshift; Positions=1, 63, 72; Evidence={ECO:0000305}; Sequence=BAE38232.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:11470804, ECO:0000269|PubMed:15525578}.
Tissue SpecificityDetected in kidney (at protein level). Detected in kidney proximal tubules and in liver. Detected at low levels in testis, stomach, heart and lung. {ECO:0000269|PubMed:11470804, ECO:0000269|PubMed:15525578, ECO:0000269|PubMed:9449642, ECO:0000269|PubMed:9507200}.