LMPD Database

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LMP006280

UniProt Annotations

Entry Information
Gene Namelysocardiolipin acyltransferase 1
Protein EntryLCLT1_HUMAN
UniProt IDQ6UWP7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6UWP7-1; Sequence=Displayed; Name=2; IsoId=Q6UWP7-2; Sequence=VSP_026181, VSP_026182; Note=No experimental confirmation available.; Name=3; IsoId=Q6UWP7-3; Sequence=VSP_044307;
Biophysicochemical PropertiesKinetic parameters: KM=39 uM for arachidonoyl-CoA (20:4) for LPIAT activity ; KM=289 uM for oleoyl-CoA (18:1) for LPIAT activity ; KM=134 uM for linoleoyl-CoA (18:2) for LPIAT activity ; KM=34 uM for stearoyl-CoA (18:0) for LPIAT activity ; KM=53 uM for palmitoyl-CoA (16:0) for LPIAT activity ; KM=54 uM for oleoyl-CoA (18:1) for LPGAT activity ; KM=36 uM for linoleoyl-CoA (18:2) for LPGAT activity ; KM=70 uM for stearoyl-CoA (18:0) for LPGAT activity ; KM=34 uM for palmitoyl-CoA (16:0) for LPGAT activity ; Vmax=3230 nmol/min/mg enzyme toward arachidonoyl-CoA (20:4) for LPIAT activity ; Vmax=7489 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPIAT activity ; Vmax=4696 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPIAT activity ; Vmax=1078 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPIAT activity ; Vmax=11203 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPIAT activity ; Vmax=5514 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPGAT activity ; Vmax=1358 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPGAT activity ; Vmax=3530 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPGAT activity ; Vmax=1673 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPGAT activity ;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
CautionPubMed:16620771 does not detect acyl-CoA
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
FunctionAcyl-CoA
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO