LMPD Database

LMP006150

Gene Information

Entrez Gene ID	2876
Gene Name	glutathione peroxidase 1
Gene Symbol	GPX1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:BHF-UCL	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProt	C	extracellular vesicular exosome
GO:0005759	TAS:Reactome	C	mitochondrial matrix
GO:0005739	IDA:BHF-UCL	C	mitochondrion
GO:0005634	IEA:Ensembl	C	nucleus
GO:0043295	IEA:Ensembl	F	glutathione binding
GO:0004602	IDA:BHF-UCL	F	glutathione peroxidase activity
GO:0047066	IEA:Ensembl	F	phospholipid-hydroperoxide glutathione peroxidase activity
GO:0008430	IEA:Ensembl	F	selenium binding
GO:0017124	IPI:BHF-UCL	F	SH3 domain binding
GO:0007568	IEA:Ensembl	P	aging
GO:0060055	IEA:Ensembl	P	angiogenesis involved in wound healing
GO:0019369	TAS:Reactome	P	arachidonic acid metabolic process
GO:0043534	IEA:Ensembl	P	blood vessel endothelial cell migration
GO:0045454	IDA:BHF-UCL	P	cell redox homeostasis
GO:0034599	NAS:ParkinsonsUK-UCL	P	cellular response to oxidative stress
GO:0001885	IEA:Ensembl	P	endothelial cell development
GO:0045444	IEA:Ensembl	P	fat cell differentiation
GO:0006749	IDA:BHF-UCL	P	glutathione metabolic process
GO:0060047	IMP:BHF-UCL	P	heart contraction
GO:0042744	IDA:BHF-UCL	P	hydrogen peroxide catabolic process
GO:0051702	IEA:Ensembl	P	interaction with symbiont
GO:0008631	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0019372	TAS:Reactome	P	lipoxygenase pathway
GO:0051450	IEA:Ensembl	P	myoblast proliferation
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0043154	IMP:BHF-UCL	P	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902042	IMP:BHF-UCL	P	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0002862	IEA:Ensembl	P	negative regulation of inflammatory response to antigenic stimulus
GO:1902176	IEA:Ensembl	P	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0090201	IMP:BHF-UCL	P	negative regulation of release of cytochrome c from mitochondria
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:1902905	ISS:ParkinsonsUK-UCL	P	positive regulation of fibril organization
GO:0051897	IEA:Ensembl	P	positive regulation of protein kinase B signaling
GO:0018158	IEA:Ensembl	P	protein oxidation
GO:0006144	TAS:Reactome	P	purine nucleobase metabolic process
GO:0006195	TAS:Reactome	P	purine nucleotide catabolic process
GO:0040029	IDA:BHF-UCL	P	regulation of gene expression, epigenetic
GO:0033599	IMP:BHF-UCL	P	regulation of mammary gland epithelial cell proliferation
GO:0043523	IEA:Ensembl	P	regulation of neuron apoptotic process
GO:0061136	IDA:BHF-UCL	P	regulation of proteasomal protein catabolic process
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0051593	IEA:Ensembl	P	response to folic acid
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0042542	IMP:BHF-UCL	P	response to hydrogen peroxide
GO:0006982	IEA:Ensembl	P	response to lipid hydroperoxide
GO:0035094	IEA:Ensembl	P	response to nicotine
GO:0010269	IMP:BHF-UCL	P	response to selenium ion
GO:0009609	IEA:Ensembl	P	response to symbiotic bacterium
GO:0009636	IEA:Ensembl	P	response to toxic substance
GO:0009410	IEA:Ensembl	P	response to xenobiotic stimulus
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0048741	IEA:Ensembl	P	skeletal muscle fiber development
GO:0043403	IEA:Ensembl	P	skeletal muscle tissue regeneration
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0001659	IEA:Ensembl	P	temperature homeostasis
GO:0006641	IEA:Ensembl	P	triglyceride metabolic process
GO:0009650	IMP:BHF-UCL	P	UV protection
GO:0042311	IEA:Ensembl	P	vasodilation

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04918	Thyroid hormone synthesis