LMPD Database

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LMP006006

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 12
Protein EntryDHB12_HUMAN
UniProt IDQ53GQ0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53GQ0-1; Sequence=Displayed; Name=2; IsoId=Q53GQ0-2; Sequence=VSP_056380, VSP_056381; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3.5 uM for estrone ;
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
DomainThe di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
FunctionCatalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
PathwayLipid metabolism; fatty acid biosynthesis.
PathwaySteroid biosynthesis; estrogen biosynthesis.
Sequence CautionSequence=AK027882; Type=Frameshift; Positions=92; Evidence= ;
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitInteracts with ELOVL1 and LASS2.
Tissue SpecificityExpressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. {ECO