LMPD Database

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LMP005977

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 4
Protein EntryLPCT4_HUMAN
UniProt IDQ643R3
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=80 uM for lysophosphatidylethanolamine ; KM=20 uM for oleoyl-CoA ; Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates ;
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
Catalytic ActivityAcyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine.
FunctionDisplays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=AAC19156.1; Type=Frameshift; Positions=328; Evidence= ; Sequence=AAC19156.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ; Sequence=AAN33178.1; Type=Frameshift; Positions=198; Evidence= ; Sequence=AAP97722.1; Type=Frameshift; Positions=188, 198; Evidence= ;
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi- pass membrane protein {ECO
Tissue SpecificityWidely expressed with predominant level in brain.