LMPD Database

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LMP004358

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, beta
Protein EntryFNTB_MOUSE
UniProt IDQ8K2I1
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO:0000269|PubMed:21520375}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:21520375}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:21520375};
FunctionEssential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269|PubMed:21520375}.
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 5 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of FNTA and FNTB. {ECO:0000269|PubMed:21520375}.