LMPD Database

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LMP002703

UniProt Annotations

Entry Information
Gene Namephosphatidylethanolamine N-methyltransferase
Protein EntryPEMT_HUMAN
UniProt IDQ9UBM1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UBM1-1; Sequence=Displayed; Name=2; IsoId=Q9UBM1-2; Sequence=VSP_037311; Note=Variant in position: 11:V->A.; Name=3; IsoId=Q9UBM1-3; Sequence=VSP_037311, VSP_046034; Note=No experimental confirmation available. Ref.5 (BAG63603) sequence is in conflict in position: 222:S->N. ;
Catalytic ActivityS-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. {ECO
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine.
Enzyme RegulationThe first methylation is rate-limiting.
FunctionCatalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis.
Sequence CautionSequence=AAF14867.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pemt/";