LMPD Database

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LMP002660

UniProt Annotations

Entry Information
Gene Namephosphatidylserine synthase 1
Protein EntryPTSS1_HUMAN
UniProt IDP48651
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48651-1; Sequence=Displayed; Name=2; IsoId=P48651-2; Sequence=VSP_055980; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=67 uM for serine (in the presence of 2 mM PC) ; KM=24 uM for serine (in the presence of 1 mM PE) ; pH dependence: Optimum pH for both PC and PE is between 7.0 and 7.5. ;
Catalytic ActivityL-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
DiseaseLenz-Majewski hyperostotic dwarfism (LMHD) [MIM
Enzyme RegulationRequires calcium ions. Activated by exogenous phosphatidylethanolamine. {ECO
FunctionCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
PathwayPhospholipid metabolism; phosphatidylserine biosynthesis.
SimilarityBelongs to the phosphatidyl serine synthase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO