LMPD Database

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LMP002363

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily F, polypeptide 3
Protein EntryCP4F3_HUMAN
UniProt IDQ08477
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=2; Name=CYP4F3A; IsoId=Q08477-1; Sequence=Displayed; Name=CYP4F3B; IsoId=Q08477-2; Sequence=VSP_047193;
Catalytic Activity(5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O. {ECO
Catalytic Activity(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
Catalytic ActivityDocosahexaenoate + NADPH + O(2) = 22- hydroxydocosahexaenoate + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI
Enzyme RegulationInhibited by carbon monoxide (CO).
FunctionIsoform CYP4F3A
FunctionIsoform CYP4F3B
PathwayLipid metabolism; leukotriene B4 degradation.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificityIsoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cyp4f3/";