LMPD Database

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LMP002114

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Protein EntryCDS2_HUMAN
UniProt IDO95674
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95674-1; Sequence=Displayed; Name=2; IsoId=O95674-2; Sequence=VSP_015477, VSP_015480, VSP_015482; Note=No experimental confirmation available.;
Catalytic ActivityCTP + phosphatidate = diphosphate + CDP- diacylglycerol.
Developmental StageNo expression detected at E10.5 in the developing brain. At E12.5 expression is detected in the developing sentral nervous system and peripheral nervous system. At E17.5 high levels of expression are detected in a number of sites, including the dorsal root ganglia of the peripheral nervous system and the ganglion cell layer of the neural retina in the developing eye. At this stage expression in the brain is restricted to the ventricular zone of the telencephalon, in particular in the basal ganglia and the cerebral cortex.
FunctionProvides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
SimilarityBelongs to the CDS family.
Subcellular LocationMitochondrion inner membrane ; Multi-pass membrane protein ; Matrix side .
Tissue SpecificityWidely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas.