LMPD Database

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LMP002094

UniProt Annotations

Entry Information
Gene Namesialidase 3 (membrane sialidase)
Protein EntryNEUR3_HUMAN
UniProt IDQ9UQ49
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQ49-1; Sequence=Displayed; Name=2; IsoId=Q9UQ49-2; Sequence=VSP_054145;
Biophysicochemical PropertiespH dependence: Optimum pH is 3.8.;
Catalytic ActivityHydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO
FunctionPlays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO
Sequence CautionSequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the glycosyl hydrolase 33 family.
SimilarityContains 3 BNR repeats.
Subcellular LocationCell membrane ; Peripheral membrane protein .
Tissue SpecificityHighly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NEU3ID44505ch11q13.html";