LMPD Database

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LMP001921

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, gamma 90kDa
Protein EntryDGKG_HUMAN
UniProt IDP49619
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P49619-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P49619-2; Sequence=VSP_001267; Note=May be inactive.; Name=3; IsoId=P49619-3; Sequence=VSP_039922;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationRequires phosphatidylserine for maximal activity.
FunctionReverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family.
SimilarityContains 1 DAGKc domain. {ECO
SimilarityContains 2 EF-hand domains. {ECO
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular LocationCytoplasm. Membrane. Note=Can be loosely bound to the membranes.
Tissue SpecificityPredominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.