LMPD Database

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LMP001544

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 8 family, member A1
Protein EntryAL8A1_HUMAN
UniProt IDQ9H2A2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H2A2-1; Sequence=Displayed; Name=2; IsoId=Q9H2A2-2; Sequence=VSP_029972; Note=Lacks enzymatic activity.; Name=3; IsoId=Q9H2A2-3; Sequence=VSP_039759, VSP_039760; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=4; IsoId=Q9H2A2-4; Sequence=VSP_043279; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=17.5 uM for benzaldehyde ; KM=3.15 uM for 9-cis-retinal ; pH dependence: Optimum pH is 9. ;
FunctionConverts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).
Sequence CautionSequence=AAI14474.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence= ;
SimilarityBelongs to the aldehyde dehydrogenase family.
Subcellular LocationCytoplasm .
Tissue SpecificityHighly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney.