LMPD Database

LMP001190

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase, long chain base subunit 2
Protein EntrySPTC2_HUMAN
UniProt IDO15270
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI
DiseaseNeuropathy, hereditary sensory and autonomic, 1C (HSAN1C) [MIM
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=BAA25452.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
SubunitHeterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1/SPTLC1, LCB2 (SPTLC2 or SPTLC3) and ssPT (SPTSSA and SPTSSB).
Tissue SpecificityWidely expressed.