LMPD Database

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LMP000464

UniProt Annotations

Entry Information
Gene NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Protein EntrySIA8A_HUMAN
UniProt IDQ92185
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92185-1; Sequence=Displayed; Name=2; Synonyms=Sat-2; IsoId=Q92185-2; Sequence=VSP_047583, VSP_047584;
Catalytic ActivityCMP-N-acetylneuraminate + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N- acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R. {ECO
FunctionInvolved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO
PathwayLipid metabolism; sphingolipid metabolism.
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=AAC37586.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA54891.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the glycosyltransferase 29 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityStrongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST8Sia I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_636";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA1";