LMPD Database

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LMP000042

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 3 family, member A2
Protein EntryAL3A2_HUMAN
UniProt IDP51648
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51648-1; Sequence=Displayed; Name=2; IsoId=P51648-2; Sequence=VSP_001283;
Catalytic ActivityAn aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
DiseaseSjoegren-Larsson syndrome (SLS) [MIM
FunctionCatalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
SimilarityBelongs to the aldehyde dehydrogenase family.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.