LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013450

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 2
Protein EntryPLPL2_RAT
UniProt IDP0C548
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionCatalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)
InductionIncreased by rosiglitazone in subcutaneous and visceral white adipose tissue
PathwayGlycerolipid metabolism; triacylglycerol degradation.
PtmMay be phosphorylated
PtmPhosphorylation at Ser-398 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity
SimilarityContains 1 patatin domain
Subcellular LocationLipid droplet . Cell membrane {ECO:0000250}; Single-pass type II membrane protein .
SubunitInteracts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; interacts at one site of interaction (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN (By similarity). Interacts with PLIN5; prevents interaction with ABHD5. {ECO:0000250, ECO:0000269|PubMed:23408028, ECO:0000269|PubMed:24303154}.