LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013291

UniProt Annotations

Entry Information
Gene NameVac14 homolog (S. cerevisiae)
Protein EntryVAC14_RAT
UniProt IDQ80W92
SpeciesRat
Comments
Comment typeDescription
Developmental StageExpressed in embryonic brain
DomainThe C-terminal domain (residues 524-783) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex
FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity)
SimilarityBelongs to the VAC14 family
SimilarityContains 6 HEAT repeats
Subcellular LocationEndosome membrane . Microsome membrane . Note=Mainly associated with membranes of the late endocytic pathway
SubunitForms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity). Interacts with NOS1. {ECO:0000250, ECO:0000269|PubMed:17161399}.
Tissue SpecificityExpressed in brain, lung, kidney and testis with highest levels in brain and testis