LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013258

UniProt Annotations

Entry Information
Gene Namelipoic acid synthetase
Protein EntryLIAS_RAT
UniProt IDQ5XIH4
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityProtein N(6)-(octanoyl)lysine + 2 sulfur- (sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)- (lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'- deoxyadenosine.
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence= ; Note=Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. ;
FunctionCatalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PathwayProtein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 2/2
SimilarityBelongs to the radical SAM superfamily. Lipoyl synthase family
Subcellular LocationMitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}.