LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013117

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 3
Protein EntryNUDT3_RAT
UniProt IDQ566C7
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=340 nM for PP-InsP5; KM=34 nM for [PP]2-InsP4;
Catalytic ActivityDiphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 3 Mg(2+) ions per subunit. ;
Enzyme RegulationInhibited by fluoride and InsP6
FunctionCleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate
SimilarityBelongs to the Nudix hydrolase family. DIPP subfamily
SimilarityContains 1 nudix hydrolase domain
Subcellular LocationCytoplasm .
SubunitMonomer