LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013056

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily f, polypeptide 18
Protein EntryCP4F3_RAT
UniProt IDQ3MID2
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Enzyme RegulationInhibited by carbon monoxide (CO)
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes (By similarity)
PathwayLipid metabolism; leukotriene B4 degradation.
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .