LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012920

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 9
Protein EntryDHRS9_RAT
UniProt IDQ8VD48
SpeciesRat
Comments
Comment typeDescription
Function3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationCytoplasm . Microsome membrane {ECO:0000250}. Endoplasmic reticulum membrane . Note=Associated with microsomal membranes
SubunitHomotetramer
Tissue SpecificityHighly expressed in epithelium of estrus uterus