LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012905

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Protein EntryPI42C_RAT
UniProt IDO88370
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
FunctionMay play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum
PtmPhosphorylated
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationCytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.
Tissue SpecificityWidely expressed, with the most abundant expression in kidney