LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012841

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 4
Protein EntryNUDT4_RAT
UniProt IDQ99MY2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityDiphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. ;
FunctionCleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity)
InductionOverexpressed in frontal cortex upon chronic lithium treatment
SimilarityBelongs to the Nudix hydrolase family. DIPP subfamily
SimilarityContains 1 nudix hydrolase domain
Subcellular LocationCytoplasm .