LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012810

UniProt Annotations

Entry Information
Gene Nameectonucleotide pyrophosphatase/phosphodiesterase 2
Protein EntryENPP2_RAT
UniProt IDQ64610
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64610-1; Sequence=Displayed; Name=2; IsoId=Q64610-2; Sequence=VSP_024018; Note=No experimental confirmation available.;
Catalytic Activity1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 2 Zn(2+) ions per subunit. ;
Enzyme RegulationInhibited by lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Inhibited by EDTA and EGTA (By similarity)
FunctionHydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. {ECO:0000269|PubMed:12119361, ECO:0000269|PubMed:15985467}.
PtmN-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity
SimilarityBelongs to the nucleotide pyrophosphatase/phosphodiesterase family
SimilarityContains 2 SMB (somatomedin-B) domains
Subcellular LocationSecreted {ECO:0000269|PubMed:12119361, ECO:0000269|PubMed:12633853, ECO:0000269|PubMed:15985467, ECO:0000269|PubMed:16436050, ECO:0000269|PubMed:21240271}. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Tissue SpecificityAbundantly expressed in cerebrum and cerebellum. Localized in secretory epithelial cells in the brain and the eye including choroid plexus epithelial cells, ciliary epithelial cells, iris pigment epithelial cells, and retinal pigment cells. {ECO:0000269|PubMed:16436050, ECO:0000269|PubMed:7961762}.