LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012784

UniProt Annotations

Entry Information
Gene NameInositol (myo)-1(or 4)-monophosphatase 1
Protein EntryIMPA1_RAT
UniProt IDP97697
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAlpha-D-galactose 1-phosphate + H(2)O = D- galactose + phosphate
Catalytic ActivityMyo-inositol phosphate + H(2)O = myo-inositol + phosphate
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Enzyme RegulationActivity with myo-inositol monophosphate and D- galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM
FunctionResponsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
SimilarityBelongs to the inositol monophosphatase family
Subcellular LocationCytoplasm .
SubunitHomodimer
Tissue SpecificityUbiquitous