LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012768

UniProt Annotations

Entry Information
Gene Nameprotein geranylgeranyltransferase type I, beta subunit
Protein EntryPGTB1_RAT
UniProt IDP53610
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670};
FunctionCatalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of proteins with the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B
InteractionQ04631:Fnta; NbExp=5; IntAct=EBI-602610, EBI-602447;
SimilarityBelongs to the protein prenyltransferase subunit beta family
SimilarityContains 4 PFTB repeats
SubunitHeterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}.