LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012762

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate receptor, type 2
Protein EntryITPR2_RAT
UniProt IDP29995
SpeciesRat
Comments
Comment typeDescription
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)
PtmPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release
SimilarityBelongs to the InsP3 receptor family
SimilarityContains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotetramer. Interacts with CABP1