LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012740

UniProt Annotations

Entry Information
Gene Nameferredoxin reductase
Protein EntryADRO_RAT
UniProt IDP56522
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionServes as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
PathwaySteroid metabolism; cholesterol metabolism.
SimilarityBelongs to the ferredoxin--NADP reductase type 1 family
Subcellular LocationMitochondrion matrix.
SubunitMonomer. Interacts directly with FDX1