LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012704

UniProt Annotations

Entry Information
Gene Name2,4-dienoyl CoA reductase 2, peroxisomal
Protein EntryDECR2_RAT
UniProt IDQ9Z2M4
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTrans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH
FunctionAuxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily
Subcellular LocationPeroxisome .
SubunitMonomer, dimer and oligomer