LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012683

UniProt Annotations

Entry Information
Gene Namealpha 1,4-galactosyltransferase
Protein EntryA4GAT_RAT
UniProt IDQ9JI93
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + beta-D-galactosyl- (1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl- (1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide
DomainThe conserved DXD motif is involved in enzyme activity
FunctionNecessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 32 family
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityUbiquitous. Highly expressed in kidney, mesenteric lymph node, spleen and brain