LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012659

UniProt Annotations

Entry Information
Gene Namecannabinoid receptor 2 (macrophage)
Protein EntryCNR2_RAT
UniProt IDQ9QZN9
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZN9-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9QZN9-2; Sequence=VSP_036231;
FunctionHeterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity)
PtmConstitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Perikaryon . Note=Localizes to apical dendrite of pyramidal neurons.
Tissue SpecificityExpressed in spleen and brain by neurons and glial cells (at protein level). Expressed in lung, testis and thymus but not in heart, liver or kidney. Expressed in cerebellum, cortex and brainstem. {ECO:0000269|PubMed:12084572, ECO:0000269|PubMed:12153574, ECO:0000269|PubMed:16224028, ECO:0000269|PubMed:18286196}.