LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012549

UniProt Annotations

Entry Information
Gene Namepancreatic lipase
Protein EntryLIPP_RAT
UniProt IDP27657
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate
FunctionPlays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
InductionBy colipase/CLPS in the presence of bile salts.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationSecreted.
Tissue SpecificityPancreatic secretory (zymogen) granule.