LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012545

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate receptor, type 3
Protein EntryITPR3_RAT
UniProt IDQ63269
SpeciesRat
Comments
Comment typeDescription
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
PtmPhosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity)
SimilarityBelongs to the InsP3 receptor family
SimilarityContains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
SubunitHomotetramer. Interacts with SIGMAR1, AKT1, PML and CABP1. Interacts with TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with TMBIM4/LFG4 (By similarity). Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (By similarity)