LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012470

UniProt Annotations

Entry Information
Gene Namephospholipase D2
Protein EntryPLD2_RAT
UniProt IDP70498
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylethanolamine. Inhibited by phosphatidylserine and by oleate. Is not responsive to ADP- ribosylation factor 1 (ARF1), nor to GTP-binding protein RhoA.
FunctionMay have a role in signal-induced cytoskeletal regulation and/or endocytosis
InteractionP33535:Oprm1; NbExp=3; IntAct=EBI-6140589, EBI-4392569;
PtmPhosphorylated on Tyr-11; most likely by EGFR (By similarity). Phosphorylated by FGR. {ECO:0000250, ECO:0000269|PubMed:15282299}.
SimilarityBelongs to the phospholipase D family
SimilarityContains 1 PH domain
SimilarityContains 1 PX (phox homology) domain
SimilarityContains 2 PLD phosphodiesterase domains
Subcellular LocationMembrane ; Peripheral membrane protein .
SubunitInteracts with PIP5K1B and EGFR
Tissue SpecificityExpressed in brain, lung, heart, kidney, stomach, small intestine, colon, and testis, and at a much lower levels in thymus, liver and muscle.